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pentobarbital will reduce the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.iloperidone increases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Iloperidone is a time-dependent CYP3A inhibitor and could produce elevated plasma amounts